“Therapeutic Strategies for Harnessing Human Eosinophils in Allergic Inflammation, Hypereosinophilic Disorders,
and Cancer”. Curr Allergy Asthma Rep (2012) 12:402–412
DOI 10.1007/s11882-012-0290-3
An overriding theme for the article could be summed up as eosinophil (eos.) functional paradox/duality. In some instances presence seems to be beneficial and in others detrimental (as it relates to survival of individuals with different forms of cancer). In other words there is still much to learn about eos. and it will probably be a much more complex interaction than initially thought. There is also a significant component of immune technique and applied immunology to the article. Use of monoclonal antibodies to IL-5 and the IL-5 receptor to modify immune response. This also brings into play concepts of ADCC, along with specific and family binding sites associated with IL receptors.
So for the article: Get the article , read it and answer the questions. Submit answers on black board.
1. What are the commonly recognized functions of eos.? What are beneficial activities and what are pathological activities? What activities are associated with IL-5 and what cells produce it?
2. What are the cytotoxic substances associated with eos? How does each function? And what triggers degranulation?
3. What substances produced by eos. are responsible for tissue remodeling? What role could they have in its beneficial /pathological activity?
4. What are monoclonal antibodies? What MABs are discussed in the article (name and targets)? How do they function?
5. How can MAB manipulation of eos response be beneficial in the outcome of allergy and cancer? What are differences in targeting the cytokine or the receptor or different binding sites on the receptor? How could you just block the receptor without potentially killing the cell that carries the receptor?
6. What does IgG1? mean? What is ADCC and how is it related to the article? What is TATE and how is it related to the article?
7. For potential eos. associated cancer therapy, there are general activities associated with Eos. Hypothetically, how could these activities be regulated to as an enhanced cancer therapy?
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