Use concepts from pathophysiology and pharmacology to explain the clinical manifestations and pharmacotherapy associated with hypertension, diabetes, diabetic peripheral neuropathy and depression. Evaluate assessment data to determine the effectiveness of the prescribed plan of care. Determine congruence between a prescribed plan of care and current, evidence-based clinical practice guidelines. Recommend changes to a plan of care based upon current clinical practice guidelines and identified gaps in care. The purpose of this assignment is to use concepts from both pathophysiology and pharmacology to explain the clinical best practices for the management of patients experiencing diabetes, diabetic peripheral neuropathy and depression along with the previously diagnosed hypertension. It is expected that clinical practice guidelines and evidence reports (available in Modules 2 – 4) along with information from your course textbook, videos, journal articles and web resources be used to support your answers. Additional outside research may be needed to fully answer the prompts, and outside resources are encouraged. A grading rubric will be used in the evaluation of your responses. At least three references are required, and your paper must be submitted in APA format. The paper is limited to 5 pages, not including the title and reference pages.